摘要
目的 了解有偿供血员感染丙型肝炎病毒 (HCV)、艾滋病病毒 (HIV)和乙型肝炎病毒 (HBV)的情况 ,分析HCV和HIV感染对HBsAg的影响。方法 检测 2 96名供血员血清抗 HCV、抗 HIV和HBV的 5项标志物 (HBsAg、抗 HBs、HBeAg抗 HBe及抗 HBc)。 结果 2 96例有偿供血员中 ,抗 HCV阳性 194例 ,占 6 5 .5 %。抗 HCV阳性者中 ,抗 HIV阳性为 14 5例 ,占HCV总阳性的 75 %。本组AIDS患者均死于肝外感染或肿瘤而非肝病。HCV合并HIV感染组的HB sAg阳性率为 2 .8% ,明显低于单纯HCV和单纯HIV感染者 (10 % ) ,两组比较差异有显著性 (P <0 .0 5 )。结论 在HIV高发区 ,抗 HCV阳性有偿献血员常合并HIV感染 ,是AIDS高危人群。HCV合并HIV感染 。
Objective To investigate the prevalence of hepatitis C virus(HCV), human immunodeficiency virus( HIV) and hepatitis B virus(HBV) among paid blood donors and to analyze the effect of HCV and HIV on production of hepatitis B virus surface antigen(HBsAg).Methods Antibodies against hepatitis C virus (anti HCV) and human immunodeficiency virus (anti HIV), and five serum markers of hepatitis B virus (HBVM) were determined by ELISA in 296 paid blood donors. Results One hundred and ninety four samples from 296 donors(65.5%) were positive for anti HCV . In the donors who were infected by HCV, 145 samples (75%) were positive for anti HIV. Thirteen patients with AIDS died. The causes of death were infections and/or carcinoma,but not liver disease. The positive rate of HBsAg(2.8%) was lower among the donors infected with both HCV and HIV than that of the donors infected with HCV or HIV alone (10%)(P<0.05). Conclusion In high epidemic areas of HIV blood donors with HCV infection are at high risk of HIV infection. Superinfection of HCV and HIV may interfere the production of HBsAg.
出处
《临床内科杂志》
CAS
北大核心
2001年第4期308-309,共2页
Journal of Clinical Internal Medicine
