摘要
目的 观察血管内皮生长因子 (VEGF)及 β3整合素在肉芽组织血管生成中表达的动态变化。 方法 RT PCR法及免疫组织化学法观察人正常皮下组织、增殖期肉芽组织 (伤后 7～ 12天 )和成熟期肉芽组织 (伤后 30～ 35天 )VEGF及 β3整合素mRNA及蛋白的表达。结果 VEGF及 β3整合素在正常皮下组织表达很低 ,在增殖期肉芽组织中表达明显升高 ,而肉芽组织成熟后其表达又降低。结论 VEGF及 β3整合素是血管生成过程中重要的调节因子。
Objective To observe the changeabl e expressions of vascular endothelial growth factor (VEGF) and integrin β3 during the angiogenetic process of granulation tissue. Methods mRNA and protein of VEGF and integrin β3 in human normal subcutaneous tissue, proliferative granulation tissue and ma ture granulation tissue were observed by RT-PCR and immunohistochemistry staini ng. Results The expressions VEGF and integrin β3 were low in normal subcutaneous tissue and were much higher in proliferative gra nulation tissue. When the granulation tissue was mature, the expression was decr eased again. Conclusion VEGF and integrin β3 are important regulating factors in angiogenesis.
出处
《中国普外基础与临床杂志》
CAS
2001年第6期378-380,共3页
Chinese Journal of Bases and Clinics In General Surgery
