摘要
1 ,3 二异丙基脒基 2 硫代 乙酸盐酸盐经Vilsmeier试剂活化后 ,与带有保护基的 7 ACA缩合得到头孢硫脒 ,收率由 45 %提高到 5 6%。本方法操作简便 ,适宜于规模生产。
The (1,3-diisopropylamidino)-2-thio-acetic acid hydrochloride was activated by the Vilsmeier agent and condensed with protected 7-ACA to form cephathiamidine.The yield was increased from 45% to 56%.The process was easy to control,which fitted the production on a scale.
出处
《中国药物化学杂志》
CAS
CSCD
2001年第5期293-294,共2页
Chinese Journal of Medicinal Chemistry
关键词
头孢菌素
头孢硫脒
合成
cephalosporin
cephathiamidine
synthesis
