摘要
为研究和比较国产重组 (酵母 )乙型肝炎 (乙肝 )疫苗与血源乙肝疫苗的免疫效果 ,采用单纯随机方法 ,于免疫后 1年对重组 (酵母 )乙肝疫苗接种的新生儿进行随访观察 ,采血检测乙肝病毒表面抗原 (HBsAg)、乙肝病毒表面抗体 (抗 -HBs)、乙肝病毒核心抗体 (抗 -HBc)。HBsAg阳性母亲所生的儿童其HBsAg阳性率为 5 2 % (4 /77) ,抗 -HBs阳性率为 83 3% (6 5 /78) ,疫苗保护效果为 91 3% ;HBsAg阴性母亲所生的儿童其HBsAg阳性率为 0 9% (1/114) ,抗 -HBs阳性率为 97 4% (111/114) ,疫苗保护效果为 79 5 %。重组 (酵母 )乙肝疫苗有较好的近期保护效果和免疫原性 。
For investigating the immune efficacy of domestic yeast-derived recombinant hepatitis B vaccine that has replaced the plasma-derived one,we followed up for one year the children who had received the yeast-derived recombinant hepatitis B vaccine at their birth Blood sample was taken from each subject and tested for HBsAg,anti-HBs and anti-HBc HBsAg positive rate in children born to HBsAg positive mothers was 5 2%(4/77), anti-HBs positive rate was 83 3%(65/78)and the protective efficacy was 91 3% For children born to HBsAg-negative mothers,thses figures were 0 9%(1/114),97 4%(111/114)and 79 5%,respectively Thus,the yeast-derived recombinant hepatitis B vaccine is as good as plasma-derived one in terms of short-term efficacy and immunogenicity
出处
《中国计划免疫》
2001年第5期259-261,共3页
Chinese Journal of Vaccines and Immunization
关键词
乙型肝炎
重组(酵母)乙肝疫苗
免疫效果
Yeast-derived recombinant hepatitis B vaccine
HBsAg
Protective efficacy
