摘要
采用碘化油与大剂量阿霉素、丝裂霉素、顺氯铵铂等化学栓塞剂,经导管对癌灶及肿瘤血管进行充分栓塞,并用较大剂量白细胞介素-2、α-干扰素经肝动脉灌注行过继免疫,治疗124例次中晚期原发性肝癌(包括2例肝癌破裂出血)。其中单纯型Ⅱ期35例次,Ⅲ期2例次;硬化型Ⅱ期82例次,Ⅲ期3例次;炎症型Ⅱ期2例次。经治疗总有效率达93.5%,其中瘤体缩小50%以上者达32.3%。到目前为止,全组治疗后平均生存期达7.6个月。但重复栓塞治疗4次以上的6例中,4例产生侧枝循环,影响了远期疗效的进一步提高。
In recent two years we have treated 124 cases of middle or terminal primary hepatocellular carcinoma (PHC) by using transcatheter arterial chemoembolization (TACE) with medicines such as lipiodol mixed with large doses of Adriamyein (ADM), Mitomycin (MMC) and Cis-platin (CDDp) for sufficient embolization of the cancerous focus and their feeding vessels, and by using relatively large doses of interleukin 2 (IL-2) and a-interferon (a-IF) for intraarterial adoptive immunotherapy. In the series including 2 cases of bleeding from spontaneous tumour rupture, there were 37 eases of simple type (35 in stage Ⅱ, and 2 in stage Ⅲ), 85 cases of cirrhotic type (82 in stage Ⅱ, and 3 in stage Ⅲ), and 2 cases of inflammatory type (all in stage Ⅱ). After the treatment the total effective rate was 93.5%, and in 32.3% of the eases the turnouts reduced by more than 50% in size. In the 2 cases of tumour rupture, bleeding was immediately controlled and the tumours became obviously smaller. In the 2 cases of inflammatory type the symptoms were rapidly relieved, the temperature went down, and the liver functions returned to normal. Up to now, average postoperative survival time was 7.6 months. However, in 4 of the 6 cases treated more than 4 times with TACE, collateral circulation occurred and influenced the further increase in the long-term therapeutic effects.
出处
《南通医学院学报》
1991年第2期102-104,129,共4页
ACTA Academiae Medicinae Nantong
关键词
肝肿瘤
化学栓塞术
中晚期
TACE
: middle or terminal primary hepatocellular carcinoma
transcatheter arterial chemotherapeutic embolization (TACE)
adoptive immunotherapy
interleukin 2 (IL-2)
α-interferon (α-IF)
