摘要
抗精神病药物的致肥胖率约为20%～40%,肥胖增加患者心理负担与消极情绪,有碍疾病的康复。芬氟拉明(Fenfluramine)与抗精神病药物合并应用,于第12周末男性平均体重下降4.18kg,女性3kg,与对照组相比有明显差异(P<0.001,P<0.01)。药物副反应轻微,对精神症状的改善无不良影响。
The prevalence of obesity ranges from 20% to 40% in patients receivingantipsychotic drugs. The obesity would be a burden to the patients'mind and induce pessimismas well as impede their rehabilitation.The mean weight loss of men and women afterthe completion of the 12 weeks were 4.18 kg and 3 kg respectively, among 30 patients,when Fenfluramine and antipsychotic-durgs treatment combined. Compared with the controlgroup the differences were significant (P<0. 001, P<0. 01).The side-effects of fenfluraminewere mild, no adverse influence on the psychotic symptoms was observed.
关键词
安定
芬氟拉明
肥胖
tranquilizing agents, major
Fenfluramine
obesity
