摘要
目的 观察全反式维甲酸 (ATRA)与 5 FU和MMC联合治疗晚期胃癌的疗效。方法 用ATRA治疗晚期胃癌。 5 FU/ARTA/MMC联合化疗 :5 FU 5 0 0～ 75 0mg/m2 ,第 1～ 5天iv ,ATRA 2 0mg ,口服 ,每日 3次 ;MMC 6～8mg/m2 ,iv ,每周 2次。 5 FU/ADM /MMC方案 ,5 FU 5 0 0～ 75 0mg/m2 ,第 1～ 5天iv ,ADM 3 0mg/m2 ,iv ,连用 2日 ,MMC6～ 8mg/m2 ,iv ,每周 2次。联合化疗每 2 8天重复为一周期。结果 5 FU/ATRA/MMC治疗 15例胃癌的有效率为 60 .0 % (9/15 ) ,5 FU /ADM /MMC治疗 15例胃癌的有效率为 40 .0 % (6/15 )。前一方案的有效率高于后者 (P <0 .0 5 ) ,两者毒副反应相似 ,但多数患者能耐受。另外 ,ATRA主要对高、中分化的胃癌作用明显。结论 ATRA与 5 FU/MMC联用能明显提高化疗药物对高。
Objective To study the effect and toxicity of ATRA in the treatment of gastric cancer.Methods In combination regimens,15 gastric cancer patients received 5-FU at a dose of 500～750mg/m 2 daily on days 1 through 5;ATRA 20mg daily,and MMC 6～8mg/m 2 twice a week;15 patients with gastric cancer received 5-FU 500～750mg/m 2 daily on days 1 through 5;ADM 30mg/m 2 daily for two days,and MMC 6～8mg/m 2 twice a week.Treatment was recycled every 28 days and one course consisted of two cycles.Results The response rate of 15 gastric cancer treated by 5-FU/ATRA/MMC was 60.0%(9/15),much higher than that of 15 patients treated by 5-FU/ADM/MMC(P<0.05).The adverse effects of 5-FU/ART/MMC group were the same as that of 5-FU/ADM/MMC group.ATRA was effective maily for high and middle differentiated gastric cancer.Conclusions ATRA combined with 5-FU/MMC is effective in treating advanced gastric cancer of high and middle differentiated.
出处
《中国肿瘤临床与康复》
2001年第3期91-92,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
胃癌
全反式维甲酸
药物治疗
stomach neoplasm
all trans retinoic acid
drug therapy
