摘要
目的 :探讨低剂量 X射线全身照射对小鼠松果腺细胞周期的影响。方法 :采用流式细胞术(FCM)检测小鼠松果腺细胞周期。结果 :低剂量电离辐射全身照射后 ,小鼠松果腺 G0 / G1期细胞百分数降低 (P<0 .0 5 ) ,S期细胞百分数升高 (P<0 .0 1) ,G2 + M期细胞百分数降低 (P<0 .0 5 )。结论 :低剂量电离辐射可促进小鼠松果腺细胞的 DNA合成及增殖。
Objective:In the present study we observed the effect of low dose radiation (LDR) on cell cycle of pineal gland in mice.Methods:The distribution in the phase of the cell cycle was analyzed by flow cytometry after staining of pineal gland with propidium iodine (PI) after WBI with 75 mGy X rays.Results:It was shown that the percentage of G 0/G 1 phase and G 2+M phase of pineal gland cells decreased after irradiation ( P <0 05),and meanwhile the percentage of S phase of pineal gland cells increased after irradiation ( P <0 01). Conclusion:These results indicated that WBI with LDR could promote DNA synthesis of pineal gland cells in mice.
出处
《白求恩医科大学学报》
CAS
CSCD
北大核心
2001年第5期502-503,共2页
Journal of Norman Bethune University of Medical Science
