摘要
采用发色底物法等测定 5 3例肝硬化患者TFPI活性 (TFPI∶C)及血清脂蛋白水平。发现肝硬化患者TFPI∶C、高密度脂蛋白 (HDL -C)、低密度脂蛋白 (LDL -C)、极低密度脂蛋白 (VLDL -C)、脂蛋白 (α) [Lp(α) ]均低于正常对照组 (p均 <0 .0 1) ;肝功能损害程度越重 ,上述指标下降越明显 ;合并门静脉系血栓形成 (PT)组各项指标低于无合并PT组 ;肝硬化患者TFPI∶C水平与HDL -C、LDL -C、VLDL -C及Lp(α)水平呈正相关。提示肝硬化患者血清脂蛋白水平可能是TFPI活性降低的主要原因之一 。
To study the clinical significance of tissue factor pathway inhibitor(TFPI)and the serum lipoprotein in patients with cirrhosis,TFPI consistency(TFPI∶C)was determined with chromogenic peptide substrate method,and the serum lipoprotein were determined with an auto biochemical analyzer.In 53 pationts with cirrhosis,TFPI∶C?HDL-C?LDL-C?VLDL-C?Lp(α) were detected respectively,which are lower than those in the control (P<0.01).The more serious the liver function is,the worse the above targets are,especially in the cirrhosis pationts with trombosis of portal vein system(PT),of which the targets are lower than those without PT(P<0.01).TFPI∶C is positive correlated with the level of HDL-C?LDL-C?VLDL-C?Lp(α).The serum TFPI∶C and lipoprotein may be the makers in estimating the severity of the cirrhosis.The level of serum lipoprotein may be one of the causes to decrease the level of TFPI∶C,and the decrease of TFPI∶C may be related to the throbomsis of portal vein system in the pationts with cirrhosis.
出处
《临床肝胆病杂志》
CAS
北大核心
2001年第4期239-240,共2页
Journal of Clinical Hepatology
