摘要
遗传性非腺瘤病性结直肠癌 (HNPCC)是一种常染色体显性遗传的综合症 ,占总的结直肠癌的 5 %—10 %。该病由错配修复基因缺陷造成 ,肿瘤表现出高度的微卫星不稳。
Hereditary nonpolyposis colorectal cancer (HNPCC) is a distinct autosomal dominant syndrome, accounting for 5%-10% of the total colorectal cancer population. To date, we have noticed that patients with HNPCC inherit a germline mutation in one of the genes responsible for repair of DNA mismatch errors. Tumors of HNPCC show a high frequency of microsatellite instability. Identifying individuals afflicted with HNPCC has implications for surgical management, prognosis, follow up, and surveillance of HNPCC patients and family members at risk.
出处
《中国癌症杂志》
CAS
CSCD
2001年第5期468-470,共3页
China Oncology
