摘要
目的 :研究妊娠期乳腺癌在诊断和手术、化疗、放疗综合治疗方面的特殊性。方法 :1992年 12月—1999年 6月 ,法国巴黎第十二大学附属HenriMondor医院放疗科收治 9例妊娠期乳腺癌患者 ,其中 3例诊断于妊娠期 ,6例诊断于分娩后 1年内。 5例行乳房保留治疗 ,4例改良根治术。所有病例行术后放疗。 7例接受化疗。结果 :9例钼靶摄片中 7例和所有的 5例超声检查提示肿瘤征象 ,诊断时总体病期晚 ,Ⅰ、Ⅱ、、Ⅲ期比例分别为11%、44 %和 44 %。中位随访 6 0月 (9— 89月 )时 ,6例无病生存 ,3例在治疗结束后 14月— 48月出现局部复发或远处转移。结论 :妊娠期乳腺癌诊断延误较为常见 ,对分娩后确诊的患者 ,应重视妊娠、哺乳期乳房体检和超声检查在鉴别诊断乳房肿块中的作用。治疗原则必须兼顾疾病的迫切性和胎儿的安全性。在可以及时开展化疗和放疗的综合治疗的前提下 。
Purpose: To analyze and study the characteristics of diagnosis, multidisciplinary treatment including surgery, chemotherapy and radiotherapy of pregnancy-associated breast cancer. Methods: 9 cases of pregnancy-associated breast cancer were diagnosed and treated in the Department of radiotherapy of Henri Mondor Hospital, the Xllth University of Paris, from December 1992 to June 1999. 3 cases were diagnosed during pregnancy, while the other 6 were diagnosed within one year following pregnancy. 5 cases were treated with breast conservative therapy, 4 cases with modified radical mastectomy. Post-operative radiotherapy was delivered to all of the 9 cases, and 7 cases accepted chemotherapy. Results: 7 of the 9 mammographies and all the 5 breast ultrasonographies revealed tumor images. The stage at the diagnosis was generally late, the proportion of stage I , II and fT was 11 % , 44% and 44% respectively. The median follow-up time was 60 months (9-89 months), disease-free survival was observed in 6 cases, 3 cases had local recurrence or distant metastasis at 14 months to 48 months after the completion of treatment. Conclusions: Delay of diagnosis is frequently observed in pregnancy-associated breast cancer, especially in these cases diagnosed after delivery. Attention should be paid to the physical examination and ultrasonography of the breast during pregnancy and lactation. The principal of treatment is to take into account both the urgency of the disease and the safety of the fetus. Under the condition that the chemotherapy and radiotherapy could be delivered without delay, breast conservative treatment is feasible in early stage pregnancy associated breast cancer
出处
《中国癌症杂志》
CAS
CSCD
2001年第5期453-455,共3页
China Oncology
关键词
妊娠期乳腺癌
诊断
综合治疗
pregnancy-associated breast cancer
diagnosis
multidisciplinary treatment
