摘要
目的 :观察多巴胺、多巴酚丁胺静脉注射对幼兔外周静脉及其周围组织的损伤规律 ,为新生儿临床应用该药的防护提供依据。方法 :将 6 0只幼兔随机分为注射多巴胺、多巴酚丁胺 4h组 (A1)、8h组 (A2 )、12h组 (A3 ) ;注射生理盐水 4h组 (B1)、8h组 (B2 )、12h组 (B3 )。观察穿刺静脉及其周围组织的病理变化。结果 :A2 、A3 炎性细胞浸润明显高于A1,χ2 =7.0 32 9,P <0 .0 1;A3 上皮细胞坏死明显高于A1、A2 ,χ2 =4.44 4,P <0 .0 5。B组间无差异。结论 :多巴胺、多巴酚丁胺静脉注射对幼兔外周静脉及其周围组织的损伤随用药持续时间的延长而加重 ,提示新生儿应用该药时 。
Objective:To survey the injury regulation of Dopamine Dobutamine on periphery vein and organization in immature rabbits, provide basis for protecting injured vein and periphery organization in newborns clinical used the drug. Methods: Sixty immature rabbits were randomly divided into 6 groups: ①After intravenously Dopamine Dobutamine 4h group(A 1)8h(A 2)12h(A 3).②After intravenously normal saline 4h group(B 1)8h group(B 2)12h group(B 3).Observe pathological change in puncture vein and periphery organization. Result: Inflammatory cells infiltrate significantly increased in A 2 A 3 groups compared with A 1 group. χ 2=7.0329, P <0.01.Epithelial cells necroses statistically higher in A 3 group than those in the A 1 A 2 groups χ 2=4.444, P <0.05; Conclusions: Injury of periphery vein and organization after intravenously Dopamine Dobutamine make serious with time of the drug used lengthened. It was showed that continue intravenously time of the drug do not suitable too long on the puncture position in newborn (neonate).The mechanism is that endurance of periphery vein and organization relatives dopamine become divergence in different age user.
出处
《中华护理杂志》
CSCD
北大核心
2001年第11期805-807,共3页
Chinese Journal of Nursing
