摘要
本文研究了白细胞介素2(IL-2)和眼镜蛇毒对小鼠移植鼠肝癌的抑制作用以及对荷移植窟小鼠NK细胞杀伤活性的影响。结果表明:IL-2或眼镜蛇毒单独使用时,前者能明显增强荷瘤鼠的NK细胞活性,可是抑瘤作用不很明显;后者虽然严重地减弱荷瘤鼠的NK活性,但抑瘤作用反而较前者为强。当两者联合使用时,其抑瘤作用及NK活性则都显著提高(P<0.005)。提示IL-2与眼镜蛇毒具有良好的协同抗小鼠移植鼠肝癌的作用。
In this paper, we studied the antitumor effect of human Interleukin 2 (IL-2) and Cobra Snake Venom (CSV) on transplanted mice hepatoma in mice, and the NK activity effect of IL-2 and CSV on transplanted tumor-bearing mice. The
results indicated that as the IL-2 or CSV is used separately, the former is able to
enhance NK activity of transplanted tumor-bearing mice, but antitumor effect is not
obvious) and the latter is able to reduce significantly NK activity of transplanted tumor-bearing mice, whereas antitumor effect is enhanced than that of the former. When the combination of IL -2 and CSV were used, the NK activity and antitumor effect were significantly elevated (P<0.005). These results suggested that IL-2 and CSV possessed Synergistic antitumor effect against transplanted mice hepatoma in mice.
出处
《免疫学杂志》
CAS
CSCD
北大核心
1991年第4期248-251,共4页
Immunological Journal
关键词
白细胞介素2
眼镜蛇毒
抗肿瘤作用
Interleukis 2, Cobra Snake Venom, Tumor-bearig mice, Synergistic antitumor effect
