摘要
将 1 -取代芳基 -4-乙氧羰基 -5 -氨基 -1 ,2 ,3 -连三唑与苯甲酰氯 ,氯乙酰氯 ,丙酰氯 ,乙酰氯等反应合成了 2 1种标题连三唑化合物 (1 ) ,收率在 61 %～ 91 %之间 .讨论了酰氯性质与收率之间的关系 .所有含杂环化合物的结构皆用元素分析 ,IR,1H NMR及 MS作了表征 .筛选了它们对以下细菌的抑菌性能 :Klebsiella,Escherichia coli,Psendomonas aeruginosa,Stephlococcusaureus和
Twenty one new derivatives of 1 substituted aryl 4 ethoxy carbonyl 5 amino 1,2,3 triazole(compound 1) were obtained by reactions of 1 aryl 4 ethoxycarbonyl 5 amino 1,2,3 triazoles with benzoyl chloride, chloroacetyl chloride, propionyl chloride, acetyl chloride etc., in good yields( 61%~ 91%). The relationships between yields and properties of acyl halides were discussed. The structures of all heterocyclic compounds were characterized by elemental analyses, IR, 1H NMR and MS. Their antibacterial activities against Klebsiella, Escherichia coli, Pseudomonas aeruginosa, Staphlococcus aureus and Proteus vulgaris were screened.
出处
《应用化学》
CAS
CSCD
北大核心
2001年第10期772-776,共5页
Chinese Journal of Applied Chemistry
基金
国家自然科学基金资助项目 ( 2 99330 5 0 )
