摘要
目的 :在4℃、25℃、37℃下考察天林与不同 pH值的5 %葡萄糖注射液 (5 %GS)、葡萄糖氯化钠注射液 (GNS)、小儿维持液注射液在不同时间下的配伍稳定性。方法 :采用正交试验的方法 ,将天林用以上3种输液配成不同pH值的9份溶液 ,按4因素、3水平进行L9(34)正交试验 ,然后用紫外分光光度法测定各配伍液中天林的含量变化。结果 :配伍液在上述各温度、pH值输液中 ,0h～8h内天林的含量均无显著性变化。结论 :天林可与上述3种输液配伍。
OBJECTIVE:To observe the stability of mezlocillin sodium in 5% glucose injection,glucose and sodium chloride injection and maintain solution for infants injection with different pH,over different periods and at 4℃,25℃,37℃ ME_THODS:9 solutions with different pH were made up by mezlocillin sodium and above-mentioned infusion fluids,according to 4 factors and 3 levels to make L9(34) orthogonal test Then determination of mezlocillin sodium in each solution was carried out with ultraviolet spectrophotometry RESULTS:The contents of mezlocillin sodium in above-mentioned solutions with different pH and at different temperature have not changed obviously over 0h-8h CONCLUSION:Mezlocillin sodium is compatible with above-mentioned solutions
出处
《中国药房》
CAS
CSCD
2001年第6期369-370,共2页
China Pharmacy
关键词
天林
正交法
输液
稳定性
mezlocillin sodium
orthogonal test
infusion fluid
stability
