摘要
目的 探讨p5 3、bcl 2蛋白表达在卵巢子宫内膜异位症 (内异症 )癌变过程中的作用。方法 采用免疫组化法检测卵巢子宫内膜异位症组 (内异症组 ,2 2例 )、卵巢异位子宫内膜腺上皮不典型增生组 (不典型增生组 ,14例 )、卵巢子宫内膜异位症癌变组 (癌变组 ,2 2例 )的p5 3、bcl 2蛋白表达。结果 癌变组bcl 2蛋白表达阳性率显著高于内异组 (P <0 .0 5 ) ,不典型增生组bcl 2蛋白表达阳性率显著高于内异组 (P <0 .0 1) ;癌变组p5 3蛋白表达阳性率显著高于不典型增生组 (P <0 .0 1)及内异组 (P <0 .0 1) ,癌变组癌变区p5 3蛋白表达阳性率显著高于内异区 (P <0 .0 5 ) ;癌变组内异区bcl 2蛋白表达阳性率显著高于内异组 (P <0 .0 5 ) ,不典型增生组内异区bcl 2蛋白表达阳性率显著高于内异组 (P <0 .0 1)。bcl 2、p5 3蛋白表达与绝经与否、肿瘤期别、生存期无明显相关性 (P >0 .0 5 ) ;癌变组癌变区p5 3、bcl 2蛋白表达无明显相关性 (P >0 .0 5 )。结论 p5 3、bcl 2的过度表达可能参与了内异症癌变的过程 ,p5 3蛋白阳性或bcl
Objective To study the impact of bcl 2 and p53 protein expressions on the malignant transformation of ovarian endometriosis.Methods Immunohistochemical technique was used to detect the bcl 2 and p53 protein expressions in: endometriosis (GroupⅠ,22 patients), atypical hyperplasia of ectopic ovarian endometrial glands (GroupⅡ, 14 patients) and endometriosis with malignant change (GroupⅢ, 22 patients).Results The positive bcl 2 protein expression rate of Group Ⅲ was apparently higher than that of Group Ⅰ( P <0.05); The positive bcl 2 protein expression rate of Group Ⅱ was clearly higher than that of Group I( P <0.01).The positive p53 protein expression rate of Group Ⅲ was higher than that of Group Ⅱ ( P <0.01) and Group Ⅰ ( P <0.01) ;In Group Ⅲ,the positive p53 protein expression rate was higher in the malignant transformation area than in the endometriosis area ( P <0.05);In Group Ⅲ, the positive bcl 2 protein expression rate in the endometriosis area was higher than that of Group Ⅰ( P <0.05); In Group Ⅱ, the positive bcl 2 protein expression rate in the endometriosis area was higher than that of Group Ⅰ( P <0.01);However, the bcl 2 and p53 protein expressions were not related to the menopause,stage of disease or the survival ( P >0.05),nor were they related to the malignant transformation area in GroupⅢ ( P >0.05).Conclusion It is possible that the over expressions of bcl 2 protein or p53 protein play an important role in the malignant transformation of ovarian endometriosis.The bcl 2 protein (+) or p53 protein (+) endometriosis may signify a precancerous lesion. [
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2001年第5期403-405,共3页
Chinese Journal of Oncology
