摘要
目的 探讨肝硬化患者血浆内皮素 1(ET 1)的变化及其与肝功能损伤、门脉高压和肝肺综合征(HPS)的关系。方法 用放免法和自动血气分析仪检测 2 0例正常对照者、5 0例肝硬化患者血浆ET - 1和动脉血氧分压。结果 肝硬化组血浆ET 1水平显著高于对照组。血浆ET 1与肝功能降低、门脉高压密切相关。肝硬化组肺泡 动脉血氧分压差 (AaDpO2 )显著高于对照组 ;动脉血氧分压 (PaO2 )明显低于对照组。低氧血症在肝功能C级患者最为明显 ,肝性低氧血症与门脉高压相关。相关分析显示肝硬化门脉高压患者血浆ET 1和AaD pO2 间存在明显正相关 ;血浆ET 1和PaO2 间存在负相关。结论 肝硬化患者血浆ET 1水平反映了肝硬化的严重程度。ET 1可能由肝损伤所致 。
Objective To investigate the plasma level of endotheline-1(ET-1) to assess its role in liver injury, portal hypertension and hepatopulmonary syndrome in cirrhotic patients. Methods With radioimmunoassay and automatic blood gas analyzer, the levels of plasma ET-1 and arterial oxygen were detected in 20 normal subjects as controls and 50 cirrhotic patients. Results The plasma ET-1 level was significantly higher in cirrhotic patients than that in the controls. Plasma ET-1 was correlated with decreased liver function and portal hypertension in cirrhotic patients. Alveolar arterial oxygen gradients (AaDpO 2) were significantly higher in cirrhotic patients than those in the controls. Partial oxygen pressure of arterial blood (PaO 2) was significantly lower in cirrhotic patients than that in the controls. Hypoxemia occurred mainly in patients with Child Pugh C, which was correlated with portal hypertension. Correlation analysis showed positive correlation between plasma ET-1 and AaDpO 2 in cirrhotics and portal hypertension patients; there was negative correlation between plasma ET-1 and PaO 2. Conclusion The plasma level of ET-1 is closely related with the severity of liver cirrhosis. It is probable that liver injury causes higher ET-1 which is important in the pathogenesis of cirrhotic portal hypertension and HPS.(Shanghai Med J, 2001,24∶612 614)
出处
《上海医学》
CAS
CSCD
北大核心
2001年第10期612-614,共3页
Shanghai Medical Journal
