摘要
目的 :观察细菌溶解产物对轻、中度慢性阻塞性肺疾病 (COPD)急性加重的防治疗效及不良反应。方法 :轻、中度COPD病人 119例 ,随机分成细菌溶解产物治疗组 (下称治疗组 ) 59例 (男性 4 2例 ,女性 17例 ,年龄 6 8a±s10a) ,在常规治疗基础上加服细菌溶解产物 7mg .d- 1,每月服 10d ,共 3mo ;对照组 6 0例 (男性 4 8例 ,女性 12例 ,年龄 6 9a± 10a) ,为常规治疗。观察 2组病人用药后 6mo内临床状况。结果 :治疗组病人免疫细胞活性增强 ;COPD急性加重次数显著减少 ,治疗 4～ 6mo治疗组和对照组分别为 0 .2次± 0 .4次 ,0 .3次± 0 .5次 (P <0 .0 5)。病人耐受性好。结论
AIM:To observe the preventive effects and adverse reactions of bacterial lysates(BL) for acute exacerbation of mild to middle chronic obstructive pulmonary diseases(COPD). METHODS:one hundred and nineteen patients with mild to middle COPD were randomly divided into two groups: the treatment group of 59 patients (M 42,F 17;age 68 a± s 10 a)received general and BL treatment 7 mg·d -1 for 10 d every month for 3 mo.The control group of 60 patients (M 48,F 12;age 69 a ±10 a)received only general treatment.All patients were followed up for 6 mo. RESULTS:In treatment group,T lymphocyte and NK cell activity were obviously increased and times of acute exacerbation of COPD were decreased .After 4-6 mo therapy,the times of exacerbation of COPD were(0.2±0.4)times in treatment group,while (0.3±0.5)times in the control group.( P <0.05).The patients were general well tolerated. CONCLUSION:BL is an effective and safe drug in improvement of recurrent lower respiratory tract infecton in COPD.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2001年第4期252-254,共3页
Chinese Journal of New Drugs and Clinical Remedies
关键词
阻塞性肺疾病
呼吸道感染
细菌溶解产物
obstructive lung disease
respiratory tract infections
bacterial lysates [
