摘要
目的 探讨不同类型胃息肉与幽门螺杆菌 (Hp)感染以及与胃粘膜炎症、萎缩 和肠上皮化生的相关性。方法 对 2 203例胃粘膜活检发现的 278例胃息肉 (检出率 12.6 ％ )进行组织学分类，并对胃窦粘膜活检组织同时行 Hp检测及粘膜炎症、萎缩和肠上皮化 生的观察，比较不同类型胃息肉的 Hp感染率及其与癌相关病变的关系。结果 278例息肉中 ，组织学分类以小凹上皮增生型息肉为多见，有 130例，占息肉总数的 46 8％，胃体腺 型增生性息肉 67例，占 24 1％，炎性息肉和腺瘤性息肉较少见，分别为 55例 (19.8％ )和 26例 (9.4％ )。约 53 9％的胃息肉患者存在 Hp感染，其中以小凹上皮增生型息肉 感染率最高，达 73.1％。这型息肉常伴有胃粘膜的活动性炎症，且粘膜萎缩和肠上皮化生 的发生率均接近腺瘤性病变。胃体腺型增生性息肉， Hp感染率、活动性炎症及萎缩、肠上 皮化生等发生率均较低，提示这两种息肉在组织发生和病理生物学形态上存在差异。结论 小凹上皮增生型息肉的发生可能与 Hp感染有关，且常伴有明显的活动性炎症以及粘膜萎缩 和肠上皮化生，因此可能与胃癌的发生有潜在的关系。
Objective To study H.pylori infection and the changes of muco sal inflammation， atrophy and intestinal metaplasia in the different histolog ical types of gastric polyps. Methods Two hundred and seventy－ eight cases of gastric polyps(12.6％ ) from 2 203 gastric mucosal biopsy cases were histologic ally classified and examined for the presence of Helicobacter pylori,for degree and type of inflammation,mucosal atrophy and intestinal metaplasia. Results 53. 9％ gastric polyps were infected with H.pylori,in which faveolar polyp was the highest with an infective rate of 73.1％ .The changes of active inflammation,atr ophy and metaplaisa in gastric mucosa were frequently accompanied with H.pylori positive faveolar polyps almost as same as those in adenoma.The fundic gland pol yps were usually with low rate of H.pylori infection,and the changes of mucosal active inflammation,atrophy and metaplasia were seldom observed. Conclusions Fav eolar polyps,which are different from fundic gland polyp,may caused by H.pylori infection and are usually with the changes of mucosal active inflammation,atroph y and metaplasia.
出处
《中华消化内镜杂志》
2001年第3期158-160,共3页
Chinese Journal of Digestive Endoscopy
基金
深圳市自然科学基金资助项目(20006033)
关键词
胃息肉
幽门螺杆菌
粘膜萎缩
肠上皮化生
Gastric polyp
Helicobacter pylori
Mucosal atropyh
Metapla sia
