摘要
目的 从丙型肝炎 (HC)的免疫发病机制中寻找预测干扰素治疗HC疗效的有效指标。方法 在对 32例慢性丙型肝炎 (CHC)的患者运用干扰素治疗过程中 ,动态观察了血清中 β2 -微球蛋白 (β2 -MG)的变化 ;同时检测了 30例正常人作为对照组。结果 CHC患者血清中 β2 -MG的含量明显高于正常组 (P <0 .0 5 ) ,干扰素治疗后 β2 -MG的表达量明显增加 ,其中完全应答者干扰素治疗后 β2 -MG的增加量明显高于无应答者或部分应答者(P <0 .0 5 )。结论 CHC患者肝细胞表面的HLA -Ia类抗原的过度表达是造成肝损伤的原因之一 ,β2 -MG可作为临床上预测干扰素疗效的简便。
Objective To investigate the pathogenesis of hepatitis C and the index for predicting the effect of interferon (IFN) therapy of chronic hepatitis C (CHC). Methods 32 cases of CHC were treated with interferon, the serum level of β 2-microglobulin (β 2-MG) was determined by radioimmunoassay during the treatment and 30 healthy subjects were taken as controls. Results The β 2-MG serum levels in CHC patients were significantly higher than in controls (P<0.05). The elevated β 2-MG levels before and after IFN-therapy also showed statistic discrepancy between the patients with complete responses and those with partial or no responses (P<0.05). Conclusion Over -expression of HLA-Ia in hepatocyte membranes might be one of the causes of liver damage, and β 2-MG might be used as a convenient index for predicting the effect of CHC-IFN-therapy.
出处
《徐州医学院学报》
CAS
2001年第4期301-303,共3页
Acta Academiae Medicinae Xuzhou
基金
江苏省教育厅资助课题 (0 0KJD32 0 0 0 2 )
