摘要
目的 研究鼻部和咽部T/NK细胞淋巴瘤和B细胞淋巴瘤肿瘤血管生成活性的差别。方法 用CD56及CD45RO识别T/NK细胞淋巴瘤，用CD20识别B细胞淋巴瘤，用CD34识别肿瘤内微血管，研究61例鼻部和咽部淋巴瘤的免疫表型及肿瘤内微血管密度（intratumoral microvessel density, iMVD）计数。结果 61例鼻部和咽部淋巴瘤中40例CD56及CD45RO均阳性，诊断为T／NK细胞淋巴瘤，占65．6%；CD20阳性淋巴瘤有15例（24．6%），两者发病率有显著差异(χ2 ＝ 22．4, P ＜ 0．01)。40例T/NK细胞淋巴瘤的平均每视野的iMVD(iMVD/HPF)为24．1 ± 8．7，15例B细胞淋巴瘤的iMVD/HPF为14．9 ± 3．8，两者差异有显著意义（t ＝ 3．7, P ＜ 0．05）。结论 T/NK细胞淋巴瘤的iMVD/HPF明显大于B细胞淋巴瘤，前者具有明显的肿瘤血管生成活性。
Objective To search the difference of the angiogenic activity between T/NK-cell lymphomas and B-cell lymphomas． Methods The T/NK-cell was stained immunohistochemically by CD56 and CD45 RO, the B-cell was by CD20, the microvessel endothelium was by CD34． Sixty-one cases were studi- ed to examine the immunophenotye and to estimate the intratumoral microvessel density(iMVD)． Re- sults Forty in 61 cases(65．6%) expressed the immunophenotype of both T-cell and Natural Killer cell, were diagnosed T/NK-cell lymphomas． Fifteen in 61 cases(24．6%) expressed the immunopheno- type of B-cell． There was a significant difference in incidence between the two types of lymphomas(χ2 ＝ 22．4, P ＜ 0．01)． The mean of iMVD/HPF was 24．1±8．7 in 40 cases of T/NK-cell lymphomas, while the mean of iMVD/HPF was 14．9±3．8 in 15 cases of B-cell lymphomas． The difference(t ＝ 3．7, P ＜ 0．05)was significant． Conclusion The angiogenic activity of T/NK-cell lymphomas is much more than that of B-cell lymphomas． This study shows nasal/nasopharyngeal T/NK-cell lymphomas are with evident angiogenic activity．
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2001年第4期317-319,共3页
Acta Academiae Medicinae Sinicae
