摘要
目的 :观察当归芍药散 ( DSS)对脑缺血再灌注所致记忆损伤模型的影响。方法 :建立小鼠脑缺血再灌注损伤模型 ,采用避暗实验测定小鼠记忆功能 ,并观察 DSS对其影响 ,同时测定小鼠脑内 Ca- ATP酶活性、NO含量 ,蛋白质含量及脑指数、胸腺指数、脾脏指数等。结果 :DSS可明显延长脑缺血再灌注损伤模型小鼠避暗潜伏期 ,明显抑制模型小鼠脑内 Ca- ATP酶活性、脑指数及蛋白质含量的降低 ,明显降低脑内升高的 NO含量 ,对脑缺血再灌所致小鼠脾脏萎缩有显著恢复作用。结论 :DSS可能通过升高蛋白质含量、抑制脑萎缩。
OBJECTIVE:To observe the effect of DSS on the memory dysfunction induced by ischemia reperfusion in mice. METHODS:A model of memory dysfunction induced by ischemia reperfusion was built to observe the effect of DSS on the memory dysfunction in a step through test. Meanwhile,Ca 2+ ATPase activity, NO and protein content in brain were determined, and brain, spleen and thymus index were calculated. RESULTS:DSS could significantly prolong the latency of mice in the step through test, markedly increase Ca 2+ ATPase activity, protein content,brain index and spleen index, and remarkably decrease NO content.CONCLUSION:DSS could improve the memory dysfunction induced by ischemia reperfusion, which might be related with its action of inhibition of overload of Ca 2+ , increasing protein content, brain index and spleen index, and decreasing NO content.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2001年第5期343-345,共3页
Chinese Journal of Modern Applied Pharmacy
基金
国家新药基金项目
编号 :96-5 0 1-0 5 -38
