摘要
目的探讨诱导痰技术在哮喘气道炎症检测方面的应用价值。方法对12例正常人,11例缓解期哮喘患者及10例急性发作期哮喘患者进行痰液诱导测试,并对受试者血浆及诱导痰白细胞介素-8(IL-8)、嗜酸细胞阳离子蛋白(ECP)、丙二醛(MDA)水平进行测定比较。结果33例受试者中32例完成了测试;急性发作期哮喘患者的血浆及诱导痰IL-8水平、ECP水平、MDA水平与缓解期哮喘患者相比显著增高(P均小于0.01):而缓解期哮喘患者的血浆及诱导痰IL-8、ECP、MDA水平仍明显高于正常志愿者(P均小于0.05);且哮喘患者诱导痰的IL-8、ECP、MDA水平明显高于其血浆的IL-8(P<0.05)、ECP(P<0.01)、MDA(P<0.01)水平。结论诱导痰技术安全、可靠;诱导痰IL-8、ECP、MDA水平可用于监测哮喘气道炎症。
Objective To explore the clinical value of induced sputum test in monitoring airway inflammation in asthmatic patients.Methods The induced sputum test was done in12nomal subjects and21as-thmatic subjects;The levels of interleukin-8(IL-8),eosinophil cation protein(ECP),malondialdehyde(MDA)in plasma and induced sputum in all subjects were measured.Results The levels of IL-8,ECP,MDA in plasma and induced sputum in unstable asthmatic patients were significantly higher than those in stable asthmatic(P<0.01),in which the levels of IL-8,ECP,MDA in both plasma and induced sputum were significantly higher than those in nomal subjects(P<0.05);In all asthmatic patients,the levels of IL-8,ECP,MDA in induced sputum were significanty higher than those in plasma.Conclusion The levels of IL-8,ECP,MDA in induced sputum could be used for monitoring airway inflammation in asthmatic patients.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2001年第5期432-434,共3页
Acta Academiae Medicinae Sinicae
基金
国家科委"九五"重点科技攻关资金96-906-02-04~~
