摘要
目的：研究VEGF（vascular epithelial growth factor）与PCNA（ proliferating cell nuclear antigen）在甲状腺乳头状癌、滤泡状癌及正常组织中的表达及其意义。方法：对25例甲状腺乳头状癌，7例甲状腺滤泡状癌和19例正常甲状腺组织标本，采用免疫组化检测VEGF、PCNA表达。结果：VEGF与PCNA在甲状腺乳头状癌、滤泡状癌表达阳性率无显著差异，但均显著高于正常甲状腺组织，P＜0．01；两者在甲状腺癌中的表达阳性率呈正相关关系。结论：VEGF与PCNA可作为临床辅助诊断、评价甲状腺乳头状癌和滤泡状癌生物学行为的两个重要指标。
Objective The expression of VEGF.PCNA and their biological significance were studied in folicullar thyroid cancer.papillary thyroid cancer and normal thyroid tissues． Methods Immunohistochemistry was used to examine the expression of VEGF.PCNA in specimens of 25 papillary thyroid cancer.7 follicular thyroid cancer and 19 normal thyroid tissues． Results The positive rates of VEGF and PCNA in follicular thyroid cancer and papillary thyroid cancer had no significant difference.but they were higher than those in normal thyroid tissues P＜0．01.and a positive correlation between these two expressions existed in thyroid cancer． Conclusion VEGF and PCNA might play an important role in the biological behavior of thyroid cancer and they might be the indexes for adjuvant diagnosis and evaluation for thyroid cancer．
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2001年第6期443-446,共4页
Chinese Journal of Clinical Oncology
