摘要
目的 探讨人群幽门螺杆菌 (Hp)感染的危险因素 ,为制定防制对策和措施提供科学依据。 方法以Hp 4℃PCR检测试剂盒对 2 5 2例研究对象的胃液进行检测 ,130例阳性者列入病例组 ,12 2例阴性者列入对照组 ,运用病例 -对照研究方法作流行病学研究 ,应用Mantel-Haenszel法及条件Logistic回归作单因素和多因素统计分析。结果 单因素Mantel-Haenszel法及条件Logistic回归分析结果均有显著性意义的因素有 :受教育程度、职业、家庭人口数、经济收入、居住面积、饮水来源、喝生水、在外进餐 ,而居住地仅在Logistic回归分析中有显著性意义。多因素条件Logistic回归分析结果表明 ,经济收入、喝生水及在外进餐 3个因素有非常显著性意义(P =0 0 0 0 ) ,比数比 (OR)分别为 0 70 0、 6 2 17、 9 798。阴性预测正确率为 77 0 % ,阳性预测正确率为76 2 % ,总正确率为 76 6 %。经济收入与在外进餐之间存在有交互影响 (P =0 0 0 1)。结论 经常喝生水及在外进餐可显著增加Hp感染的危险性 ,经济收入越高 ,Hp感染的危险性越低。
Objective To study the risk factors of helicobacter pylori infection in population and provide the scientific bases for enacting preventive countermeasures and measures.Methods The gastric juice was determined with Hp 4℃ PCR reagent box in 252 cases,the 132 positive cases was arranged for case group,the 120 negative cases for control group.The risk factors of helicobacter pylori infection were studied by a case-control study.The univariable and multivariable analyses were carried out by the Mantel-Haenszel and Logistic regression method.Results The results of the univariable Mantel-Haenszel and Logistic regression analyses showed that the helicobacter pylori infection was relative significantly to the education background,occupation,number of family members,income,house area,drinking source,drinking unboiled water and eating outside,and to the living community only in the Logistic regression analysis.The results of the multivariable conditional Logistic regression analysis showed that the helicobacter pylori infection was relative significantly to the income,drinking unboiled water and eating outside (P=0 000),the odds ratio(OR)were 0 700,6 217,9 798 respectively.The negative predictive percentage correct was 77 0% and the positive percentage correct 76 2%,the total percentage correct was 76 6%.There was interaction between the incomes and eating outside.Conclusion Drinking unboiled water and eating outside frequently could increase the risk of helicobacter pylori infection.The more one had high income,the more one had low risk of helicobacter pylori infection.There was interaction between the income and eating outside.
出处
《中国全科医学》
CAS
CSCD
2001年第9期721-723,共3页
Chinese General Practice
基金
湖南省教育厅科研基金资助项目 (基金号 :9715 1)
