摘要
目的 :探讨高同型半胱氨酸 (HCY)血症与冠心病 (CHD)的关系及其可能的机制。方法 :选择 112例CHD患者 (CHD组 ) ,34例健康体检者 (对照组 ) ,分别测定血浆 HCY、活化的部分凝血活酶时间 (APTT)、血浆凝血酶原时间 (PT)、纤维蛋白原 (FIB)。结果 :CHD组血浆 HCY较对照组显著升高。高 HCY的 CHD组中 APTT、PT较正常 HCY的 CHD组及对照组组显著减低 ,而 FIB则显著升高。结论 :高 HCY血症与 CHD密切相关 ,并通过影响血凝状态而参与 CH
Objective:To investigate the ac tion of homocysteine in coronary heart disease.Method:One hundred and twelve CHD patients were enrolled as CHD group and 34 health as control (C) group. The plasma levels of HCY, APTT, PT and FIB were measured.Result: Plasma level of HCY was higher significantly in CH D group than that in C group. Plasma levels of APTT and PT were lower in CHD gro up than those in C group. Plasma levels of APTT and PT in CHD group with higher HCY were lower significantly than those in CHD group with normal HCY and C group . But plasma level of FIB was higher in CHD group than that in C group.Conclusion:Homocysteine may be an importent risk factor of CHD, and it can accerelated blood coagulation.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2001年第8期358-359,共2页
Journal of Clinical Cardiology
