摘要
为观察吸入性损伤犬高原喷射通气时时吸气流与ＣＯ＿２排出关系，本文选健康大６只，静脉麻醉后，插气管导管，用三维粒子动态分析仪测定自主呼吸时吸气和呼气流速，并采集动脉血标本进行血气分析。静注司可林，当动物呼吸停止时，通入高压蒸气５ｓ，然后随机进行五种不同条件高频喷射通气。每种通气模式通气２０ｍｉｎ，观察呼气速度Ｖｅ、吸气速度Ｖｉ的变化。根据公式Ｒｅ＝Ｖｒｐ／η计算出雷诺数，同时观察ＰａＣＯ＿２、ＰａＯ＿２、ＰＩＰ的变化。结果：（１）自主呼吸时吸气为层流，呼气可能为层流，也可能为涡流；（２）高频喷射通气（ＨＦＪＶ）时呼气和吸气气流均为涡流；（３）高频双向喷射通气（ＨＦＴＪＶ）与ＨＦＪＶ相比，呼气流速显著增加（Ｐ＜０．０５），ＰａＣＯ＿２显著降低（Ｐ＜０．０５），呼气流速与ＰａＣＯ＿２呈质相关（ｒ＝－０．９２１６，Ｐ＜０．０５），同时吸气流速也有增加的趋势。提示：ＨＦＪＶ可维持吸入性损伤犬的正常通气，其机制可能与涡流有关。ＨＦＴＪＶ是在ＨＦＪＶ基础上增加了反向喷射气流，可以增进呼吸气流速度，促进ＣＯ＿２排除。
In order to observe the relationship between CO_2 elimination and respiratory airflow ofthe inhalation injured dog with High Frequency Jet ventilation,six healtht dogs were anaes-thetized with thiopentone.A 3-D partical dynamic analyzer was used to determine the inspira-tory and expiratory flow velocity, and arterial blood samples were collected for blood-airanalysis during spontaneous respiration,Intravenous muscle relaxant was given quickly.When the animals were kept apnea,vapur(105℃)was inhaled for 5 seconds。HFJV was car-ried out at random under 5 different conditions,each for 20 min, Changes in inspiratory veloc-ity(Vi),expiratory velocity(Ve)Reynold’s number,PaCO_2,PaO_2 and PIP were observd.The results showed:(1)During spontaneons respiration,inspiratory airflow was laminar flowwhen Re<1 000.expiratory airflow was either laminar or turbulent when 1 000<Re<1500.(2)During HFJV both expiratory and inspiratory airflow were turbulent when Re>1500.(3)The expiratory velocity with HFTJV increased significantly(P<0.05).PaCO_2 decreased sig-nificantly(P<0. 05)compared with that with HFJV. Obvious negative correlation was foundbetween them (r=-0. 921 6,P<0.05).Meanwhile inspiratory velocity had an increasingtendency. It is suggested that (1 )HFJV might maintain normal ventilation of inhalaItion in-jured dogs. The mechanism might be associated with turbulent flow,(2)Basing upon HFJV,HFTJV increases inverse jet airflow. Thus the respiratory airflow velocity may be increasedand CO_2 elimination improved.
出处
《江西医学院学报》
1994年第3期1-7,共7页
Acta Academiae Medicinae Jiangxi
基金
国家自然科学基金
关键词
高频喷射通气
血气分析
吸入性灼伤
二氧化碳
HFJV
麻醉术
high frequency jet ventilation/methods
gases/analysis
blood gas analysis
burns,inhalation
laboratory animals
dog
