摘要
胸腺因子D(TFD)是从猪胸腺提取的分子量小于14.4KD的多肽物质。皮下注射TFD2mg/kg,隔日一次,共3月,能够明显降低老年雄性大鼠(24月龄)心、肝组织及血浆丙二醛含量,降低心、肝、脑组织脂褐素含量,并且增强老年大鼠由Con A诱导的~3H-TdR参入脾T淋巴细胞,对老年大鼠的血浆睾酮水平降低及雌二醇/睾酮(E_2/T)比值增高略具改善作用(但未显示统计学意义)。结果提示,TFD有助于延缓机体衰老;胸腺TFD 2ml/kg提取物的抗脂质过氧化作用可能与其免疫增强作用有关。
Thymic factor D (TFD), an extract from fresh pig thymus, was administered to aged male Wistar rats (24-mo- old) at 2 mg/kg sc every other day for 3 mo. Decrease of the malondialdehyde (MDA) level in plasma, heart and liver heart and decline of the lipofuscin content in liver, heart and brain tissues were observed. TFD also enhanced H-TdR in- corporation into spleen T lymphocyte induced by Con A in these animals. It was found TFD demonstrated a slight effect on the plasma testosterone and E_2/T ratio in male agde rats. It is suggested that TFD is beneficial to retard the aging pro- cess and the effect of TFD on anti-lipid peroxidation is probably related to its immunological enhancement.
出处
《老年学杂志》
CSCD
1991年第3期167-168,共2页
关键词
衰老
胸腺
淋巴细胞增殖
性激素
Aging
Thymus
Lipid peroxidation
Lymphocyte proliferation
Sex hormone
