摘要
目的探讨骨纤维发育异常osteofibrousdysplasiaOFD的临床病理特点。方法收集17例OFD患者的临床资料,包括性别、年龄、病程、发病部位、病损大小及影像学表现等。同时复习每例标本的大体及显微镜下改变,并采用链亲和素-生物素-过氧化酶SP染色检测CytokeratinCK的表达。结果发病年龄2～15岁,平均7.2岁;病程1个月～7年,平均2.1年。女性发病高于男性(男、女之比为1∶1.4)。所有病例均累及胫骨,1例同时累及腓骨,表现为局部包块。X线片示胫骨干前方皮质增厚,呈溶骨性多囊改变,周围有轻度硬化影。组织学表现有分带现象,骨小梁周围有丰富的骨母细胞。CK检测仅2例阳性(11.8%)。10例获随访,其中8例复发,复发率为80%。结论OFD主要好发于幼儿胫骨,病程较长,具有特征性病理改变及临床表现,系一独立的疾病,与长骨造釉细胞瘤等不同。
Objective To explore the clinicopathological features of osteofibrous dysplasia (OFD). Methods All the clinicopathological information of 17 cases of OFD were reviewed,including sex,age,course and radiography or histopathology features. The expression of Cytokeratin(CK) was examined by SP. Results Age of the patients ranged from 2-15 years, and the course of the lesion ranged from 1 month to 7 years. The mean age and the mean course was 7.2 years and 2.1 years respectively. Male to female ratio was 1∶1.4. The lesions all occured in tibia, presentating with localized masses. Only one invloved with both tibia and fibula. Radiographs showed there were cystic lesions in the thickened anterior cortex of the tibia with light marginal sclerosis. Histopathology showed a zonal architecture. Abundant osteoblasts in the vicinity of the trabeculae. Only two cases were positive for CK(11.8%). 8 of 10(80%) patients recurred. Conclusion OFD is predominately involved with the tibia in children. The history is long. It has a characteristic histopathologic image and clinical progress. Its a independent entity, not the same of adamantinoma.
出处
《中华骨科杂志》
CAS
CSCD
北大核心
2001年第9期548-551,共4页
Chinese Journal of Orthopaedics
