摘要
目的 :探讨肿瘤坏死因子 (TNF)及血管内皮细胞 (CEC)损伤在妊高征发病中的作用及其相关性。方法 :用放免法测定TNF -α ,用Haladovec法测CEC聚集体数。结果 :妊高征 4 0例产前TNF -α和CEC均明显高于 2 0例正常晚妊组 (P <0 .0 1) ;产后两组差异无显著性 (P >0 .0 5 )。重度妊高征患者产前TNF -α和CEC均高于中、轻度妊高征患者 (P <0 .0 1) ,产后差异无显著性 (P >0 .0 5 )。TNF -α与CEC呈正相关 (r=0 .875 ,P <0 .0 5 )。结论 :血管内皮细胞损伤是妊高征的重要发病机理。血管内皮细胞损伤与肿瘤坏死因子含量变化呈正相关 。
Objective:To explore the effects and the correlation of tumor necrosis factor (TNF) and vascular endothelium cell (CEC) injury in pregnancy induced hypertension syndrome (PIH).Methods:TNF-α was determined by immunofluorescence,and circulating CEC aggregational body counts were counted by the method of Haladovec.Results:The TNF-α and CEC aggregational body counts in 40 cases of PIH were significantly higher than that in 20 cases of normal late pregnancy (P<0.01).There was no difference in postpartum (P>0.05).Severe PIH patients TNF-α and CEC aggregation body counts were significantly higher than that in medial or light PIH patients in prepartum (P>0.05).There were positive correlation between the CEC and TNF-α (P<0.05). Conclusions:CEC injury plays a major role in pathogenesis of PIH.The injury degree is positive correlative with PIH,and CEC injury is positive correlative with TNF-α levels.TNF maybe an important cell toxic factor in CEC injury.
出处
《现代妇产科进展》
CSCD
2001年第4期256-257,共2页
Progress in Obstetrics and Gynecology
关键词
肿瘤坏死因子
血管内皮
妊娠高血压综合征
Tumor necrosis factor
Endothelium,vascular
Pregnancy induced hypetlension syndrome
