摘要
目的观察补阳还五汤减方对血瘀豚鼠内耳血流及血液流变性的影响。方法 用肾上腺素制备急性血瘀证动物模型，用激光多普勒血流计测量耳蜗和前庭血流（ＣＢＦ，ＶＢＦ），并检测血液流变学指标。结果中药组全血粘度、红细胞滤过指数（ＦＩ）、红细胞压积（ＨＣＴ）、血浆纤维蛋白原含量、ＴＸＢ２与６—Ｋｅｔｏ—ＰＧＦ１、比值（Ｔ／Ｋ）较模型组降低（Ｐ<０．０１或Ｐ＜０． ０５），ＣＢＦ和 ＶＢＦ较模型组增加（Ｐ＜０． ０１）。结论补阳还五汤减方能够通过改善血流流变性，恢复ＴＸＡ—２ＰＧＩ２动态平衡等途径增加内耳血流，改善急性血瘀证动物模型的内耳微循环。
Objective To investigate the effect of modified formula invigorating yang for recuperation(MFIYR) on the blood flow of inner ear and rheological property in guinea pigs with blood stasis syndome (BSS). Methods Adrenaline was used to animal model of BSS, cochlear flow (CBF) and vestibular blood flow (VBF) were measured .with laser doppler technique, and hemorrheology was tested with routine procedure. Results Significantly decreased hemorrheological indexes were seen in the group of animals with BSS, such as blood viscosity, filtration index(FI), hemotocrit(HCT), fibinogen (Fib) and TXB2/6-keto-PGF, ratio (T/K),companied with significantly increased CBF and VBF in these animals, compared with that in controlling group. Conclusion MFIYR can largely increase inner ear blood flow and improve the microcirculation of inner ear in experimental animals through correctin of disturbed hemorrheology and recovery of imbalance between TXA, and PGI2.
出处
《中国中西医结合耳鼻咽喉科杂志》
2001年第4期157-159,共3页
Chinese Journal of Otorhinolaryngology in Integrative Medicine
关键词
补阳还五汤
微循环
内耳
中药
Modified formula invigorating yang for recuperation Microcirculation Inner ear
