摘要
革兰阴性菌感染所致的中毒性休克是住院病人死亡的主要原因。目前认为内毒素介导细胞的反应通过两个途径 :细胞因子的间接作用及对细胞的直接作用。本文综述内毒素激活细胞直接径路的研究进展 ,重点讨论跨膜、胞内及核内信号传导机制 ,并展望其临床应用。
Septic shock induced by gram negative bacteria is the leading cause of inpatient mortality. Now there are two ways in endotoxin induced cellular response: the indirect way of cytokines and the direct way. The article reviewed mechanisms of the direct intracellular way induced by endotoxin.Paid special attentions to the development of transmembrane, intracellular and intranuclear signalling and looked ahead the application in clinic.
出处
《肠外与肠内营养》
CAS
2001年第3期177-180,共4页
Parenteral & Enteral Nutrition
关键词
内毒素
信号传导
感染
Endotoxin
Signalling
Infection
