摘要
目的 :探讨温病气分证与微观血瘀的相关性。方法 :实验采用大肠杆菌内毒素从家兔耳缘静脉注射造成温病气分证模型 ,观察模型组病理学、血液流变学、凝血指标、细胞因子 (TNF -α、IL - 6、IL - 8)水平的改变。结果 :模型组光镜下肺脏有微血栓存在 ,且模型动物出现血液流变学及凝血指标异常 ,模型组家兔血浆TNF -α、IL - 6、IL - 8水平均较正常组升高 ,升高水平与脏器组织的损害程度一致。结论 :温病气分证存在微观血瘀。TNF -α所导致的炎症级联反应 (TNF-α→Ⅱ - 6→IL - 8)可能是温病气分证微观血瘀形成的原因之一。
Objective:To observe the the mechanism of relativity between Qifen syndrome and microcosmic blood stasis in seasonal febrile disease(SFR).Method: Qifen syndrome in SFR model was induced by colibacillary endotoxin via auricular intravenous injection.The change on pathomorphology,blood rheology,cruor indexes,and Cytokines TNF-α,IL-6,IL-8 in the model was observed. Result:it showed the existence of microthrombus in the lung via microscope in the model,it also indicated that the abnormality of blood rheology and cruor indexes,TNF-α,IL-6 and IL-8 levels increased in model group,which were confirmed with obvious damage of tissue or organ damage.
出处
《中国中医药科技》
CAS
2001年第4期209-210,共2页
Chinese Journal of Traditional Medical Science and Technology
基金
上海市卫生局资助项目No 97CJ0 3
关键词
温病气分证
病理学
血瘀
血液流变学
肿瘤坏死因子
Qifen syndrome in SFR model exist microcosmic blood stasis.The inflammation cascade reaction caused by TNF-α(TNF-α→IL-6→IL-8)is perhaps one of the mechanism of microcosmic blood stasis in Qifen syndrome.
