摘要
目的 探讨血小板活化、凝血激活与不稳定心绞痛 (UA)的关系及临床意义。方法 用酶联免疫双抗体夹心法 ,分别测定 44例UA患者急性期和缓解期血浆α 颗粒膜糖蛋白 (GMP 1 40 )、D 二聚体浓度 ;并用相同方法测定 40例健康对照者上述指标 ,对其结果进行统计学分析。结果 UA患者急性期血浆GMP 1 40、D 二聚体浓度显著高于对照组 (P <0 0 1 ) ,UA患者缓解期血浆GMP 1 40、D 二聚体水平较其急性期有所下降 ,但差异无显著性 (P >0 0 5 ) ,但仍显著高于对照组 (P <0 0 5 )。结论 血小板活化、凝血激活系统及内皮细胞损伤在UA的发生发展中起重要作用。
Objective To explore the relationship between platelet activation and enhanced coagulability and the occurrence of unstable angina. Methods Plasma levels of α-granule membrane protein(GMP-140) and fibrin D-dimer were measured in 44 patients with unstable angina during the acute phase and the relief phase.The same procedure was compared with those in 40 control subjects.Results Plasma levels of GMP-140 and D-dimer were significantly higher in patients with unstable angina during both the acute phase(P<0.01) and the relief phase (P<0.05) than those in control subjects,but there was no significant difference in the patients with unstable angina between the acute phase and the relief phase(P>0.05).Conclusion It is shown that activation of platelet and coagulation system combined with endothelial injury may play an important role in the development of unstable angina.
出处
《沈阳医学院学报》
2001年第3期137-139,共3页
Journal of Shenyang Medical College
