摘要
目的 了解小儿急性白血病的免疫病理机制 ,探讨TH1 /TH2型细胞因子平衡性在发病中的作用 ,为临床免疫防治白血病提供理论依据。方法 应用双抗体夹心酶联免疫吸附法检测了 39例急性白血病患儿化疗前后血清IL 1 0和IFN γ水平 ,并进行相关性分析。结果 白血病患儿治疗前或复发时血清IL 1 0明显升高 ,IFN γ明显降低 ,治疗后病情缓解时IL 1 0水平下降而IFN γ水平升高 ,两者呈负相关关系。结论 小儿白血病的免疫病理机制与TH1 /TH2细胞功能紊乱有密切关系 ,血清IL 1 0、IFN γ水平变化可作为监测小儿白血病治疗反应的一种手段。
ObjectiveTo investigate the immunopathologic mechanism of children's acute leukemia and probe into the effect of balances amo ng TH1/TH2 type cell factors on the development of the disease, in order to brin g the theoretical basis for preventing and treating it by using immunotherapy in clinic.MethodsSerum levels of IL10 and IFN~{*2&C~} were determined in pretreatment and posttreatment respectively by ELISA and analysed by linear c orrelation in 39 children with acute leukemia.ResultsPreand posttreatmently, significantly high level of i nterleukin10(IL10) and low level of interferon~{*2&C~}(IFN~{*2&C~}) were observed in most of patients with acute leukemia(AL). Posttreatmently, the level of IL10 decreased and level of INF~{*2&C~} increased. There was a negative correlation betwe en IL10 and IFN~{*2&C~}(~{*+~}r~{*+~}=0.429, ~{*+~}P~{*+~}<0.01).ConclusionThe immunopathologic mechanism of acute leukemia wer e closely associated with functional disorders of TH1 and TH2 cell. The changes of serum IL10 and IFN~{*2&C~} level may be served as a mean of monitoring the resp onse to treatment of children with acute leukemia.
出处
《西安医科大学学报》
CAS
CSCD
北大核心
2001年第4期337-339,共3页
Journal of Xi'an Medical University(Chinese)
