摘要
目的 :研究影响厚朴三物汤中主要有效成分之一———厚朴酚煎出率的诸因素。方法 :采用HPLC法测定厚朴三物汤不同配伍及合煎、分煎组浸膏及药材残渣中厚朴酚含量 ,并用正交设计法考察大黄、枳实用量及煎煮时间、提取次数等因素对厚朴酚含量的影响。结果 :厚朴三物汤合煎组厚朴酚溶出率高于分煎组 1倍以上 ,随着枳实用量及提取次数的增加 ,厚朴三物汤中厚朴酚的溶出率升高。结论 :枳实及提取次数为影响厚朴三物汤中厚朴酚含量的主要因素。
Objective: To study the factors affecting the content of magnolol which is one of the main active components in Magnolia Bark Three Agents Decoction. Methods: The contents of magnolol in extracts of Magnalia Bark Three Agents Decoction (medicinal materids were decocted alone, together or in different compatibleness, and residuals) were determined by HPLC. The effects of use amount of Radix et Rhizoma Rhei and Fructus Aurantii Immaturus, decoction time, and extraction times on magnolol content were studied by orthogonal design.Results: The content of magnolol in Magnolia Bark Three Agents Decoction of which medicinal materials were decocted together was over double that of which they were decocted alone. The dissolution sate of magnolol increased with the increasing of the use amount of Fructus Aurantii Immaturus and extraction times. Conclusion: Fructus Aurantii Immaturuns and extraction times are the main factors affecting magnolol content in Magnolia Bark Three Agents Decoction.
出处
《中成药》
CAS
CSCD
北大核心
2001年第6期401-403,共3页
Chinese Traditional Patent Medicine
