摘要
目的：探讨血管内皮功能失调与颈动脉粥样硬化的关系。 方法：采用高分辨血管外超声法，检测４９例冠心病患者（冠心病组）和３３例具冠心病危险因素受试者（危险因素组）的肱动脉血流介导的内皮依赖性血管舒张功能（ＦＭＤ）和颈动脉内中膜厚度（ＩＭＴｃ）。 结果：冠心病组 ＦＭＤ、ＩＭＴｃ均与危险因素组相比存在着显著差异， Ｐ＜０． ０５～ ０． ００１。８２例受试者的 ＦＭＤ与ＩＭＴｃ呈显著负相关（γ＝－０． ４７４， Ｐ＜ ０．００１），但冠心病组患者的 ＦＭＤ与 ＩＭＴｃ无显著相关性（γ＝－ ０．２１３， Ｐ＝０．１４１）。 结论：冠心病患者存在显著异常的肱动脉内皮功能与ＩＭＴｃ，但两者相关性不显著。
Objective: To assess the association of endothelial dysfunction with carotid atherosclerosis. Methods: The brachial artery flow-mediated flow-mediated vasodilation (FMD)and carotid intima-media thickness (IMTc)were detected by high-resolution ultrasound technique in 49 coronary heart disease patients and 33 subjects with risk factors. Results: The patients with coronary heart disease had obviously abnormal FMD [(3.26±2.83)%vs (5.33±4.50) %, p<0.05]and IMTc (1 .09 ± 0.27 mm vs 0 .89 ± 0. 19 mm, p< 0.001)compared with the subjects with risk factors.FMD was inversely correlated with IMTc in 82 subjects. Multiple regression analyses showed that FMD exerted independent contribu- tion to IMTc.There was no significant correlation between FMD and IMTc in the patients with coronary heart disease. Conclusions: The patients with coronary heart disease had abnormal FMD and IMTc, but no significant correlation between them was found.
出处
《中国循环杂志》
CSCD
北大核心
2001年第3期183-185,共3页
Chinese Circulation Journal
