摘要
目的 了解余杭地区支原体引起泌尿生殖道感染的状况及其药物抗性频度 ,为临床治疗支原体感染提供参考依据。方法 取男性尿道分泌物或前列腺液 382份和女性宫颈分泌物 1641份 ,应用MycoplasmaIST综合试剂盒进行支原体定量培养鉴定和药物抗性频度试验 ,同时检测沙眼衣原体 (CT)、白色念珠菌和淋球菌(NG)。结果 2 0 2 3例泌尿生殖道感染患者中 ,支原体培养阳性的 747例 ,阳性率为 36 93% ,其中女性阳性率为40 16 % ,男性为 2 3 0 4% ,两者差异有非常显著意义 (P <0 0 1) ;解脲支原体 (UU)感染 410例 (2 0 2 7% )显著高于人型支原体 (MH)感染 2 9例 (1 43% )和UU +MH混合感染 30 8例 (15 2 2 % ) (P <0 0 1)。各年龄组支原体感染率 ,以 18～ 37岁年龄段最高 ,年龄组间差异有非常显著意义 (P <0 0 1)。 747例支原体感染患者中 ,合并CT感染者 5 9例 ,占 7 90 % ;合并白色念珠菌感染者 81例 ,占 10 84% ;合并NG感染者 39例 ,占5 2 2 %。药物抗性频度研究结果显示 :对红霉素的抗性频度最高 ,为 65 2 1% ,氧氟沙星和四环素次之 ,分别为2 8 5 3%和 11 0 9% ,强力霉素、原始霉素 (Pristinomycin)和交沙霉素较低 ,分别为 4 74%、 4 17%和 1 5 2 %。比较MH和UU对 6种抗生素的抗性频度 ,MH均显著高于UU (
Objective To investigate the infection of mycoplasma in genitourinary tract and its drug resistant frequently to antimicrobial agents in this area,and to provide laboratory evidence for the treatment of mycoplasma infection.Methods The quantitative culture of mycoplasma and its susceptibility to antimicrobial agents were examined by mycoplasma IST multiple reagent kits in urethra secretion or prostatic juice and uterus cervix secretion.Chlamydia trachomatis(CT),candida albicans and neisseria gonorrhoeae(NG) were simultaneously determined.Results The results indicated that mycoplasma was found in 747 of 2023 cases(36 93%),among them the rates in the women and in the men was 40 16% and 23 04% respectively,and the difference between them was significant(P<0 01).The infection rate of ureaplasma urealyticum(UU)was significant higher than that of mycoplasma hominis(MH) and mixed infection(UU+MH)(P<0 01),which infection frequently found were as follows:UU 410(20 27%),MH 29(1 43%),UU+MH 308(15 22%).The infection rate of mycoplasma was highest in 18～37 year group,and there was a significant difference between the year groups(P<0 01).Mixed infection frequently of 747 cases mycoplasma infection found were as follows:mycoplasma+CT 59(7 90%),mycoplasma+candida albicans 81(10 84%),mycoplasma+NG 39(5 22%).The drug resistant frequently to antimicrobial agents showed that to erythromycin was highest(65 12%),to ofloxacin and tetracycline subsequently(28 53%?11 09%,respectively),but to doxycycline,pristinomycin and josamycin was low(4 74%?4 17% and 1 52%,respectively).The resistant frequently of MH to 6 antimicrobial agents was significant higher than that of UU(P<0 01).Conclusion Mycoplasma is one of major pathogen of genitourinary tract infection.Now,josamycin and doxycycline is drug of first choice in treatment of mycoplasma infection in this area.One should pay attention to mixed infection in diagnos is of disease.
出处
《中国全科医学》
CAS
CSCD
2001年第8期609-611,共3页
Chinese General Practice
关键词
泌尿生殖道感染
支原体感染
药物抗性频度
Genitourinary tract Mycoplasma infection Drug resistant frequently
