摘要
氟苯水杨酸副作用小、强效、低毒,是阿司匹林很好的替代产品。公认的可工业化的生产方法是以2,4-二氟苯胺为原料,经偶联、酰化、水解、羧化等一系列反应制备。氟苯水杨酸已经在欧美、日本等70多个国家得到了广泛应用,年销售额超过1亿美元;我国浙江大学和巨化集团都对氟苯水杨酸进行了研究和开发工作,但国内尚没有工业化生产。制约氟苯水杨酸推广应用的主要原因是价格昂贵,这有赖于生产技术进步来解决。
Diflunsial is an excellent substitute product to penicillin, which is characterized by little side-effect, high efficacy and lower toxicity. The accepted commercial process is based on 2,4-difuloroaniline, through coupling, acyla-tion, hydrolysis and carboxylation reactions. Diflunsial has been widely applied in more than 70 countries and regions including Europe, the U. S. and Japan with annual sales over US $ 100m. In China, Zhejiang University and Juhua Group Corporation have undertaken the R&D of diflunsial, but there is no commercial production domestically. The high price of diflunsial has limited its popularization and application. The solution lies on the progress of manufacturing technology.
出处
《精细与专用化学品》
CAS
2001年第15期8-9,共2页
Fine and Specialty Chemicals
