摘要
目的 :探讨等位基因HLA DQA1及DQB1在国人Graves′病 (graves′disease ,GD)发病中的作用。方法 :选择汉族GD患者 10 3例及正常人 10 0例。采用PCR SSP方法 ,检验HLA DQA1 0 5 0 1、DQB1 0 2 0 1及DQB1 0 3 0 3的出现频率。结果 :HLA DQA1 0 5 0 1及DQB1 0 2 0 1GD组均低于对照组 (分别P =0 0 0 2 ,RR =0 .3 8及P =0 .0 0 1,RR =0 .2 7) ,DQB1 0 3 0 3GD组与对照组之间无差异 (P =0 .189RR =0 .64)。研究提示DQA1 0 5 0 1、DQB1 0 2 0 1为中国汉族人群GD的保护因素。以上 3种基因在不同性别GD患者之间均未见差异。结论 :HLA DQ与国人GD的发病有关。GD患者DQA1 0 5 0 1及DQB1 0 2 0 1出现频率减少。
Objective:To investigate the association of HLA DQA 1,DQB 1 with Graves′ disease in Chinese.Methods:One hundred and three patients Chinese with Graves′ disease and 100 racially matched healthy controls were studied.The frequencies of HLA DQA 1 *0501 and DQB 1 *0201 ,DQB 1 *0303 typing were determined by PCR amplification with sequence specific primers.Results:The frequencies of both HLA DQA 1 *0501 and DQB 1 *0201 were decreased in GD patients ( P=0.002,RR=0.38 and P=0.001 RR=0.27, respectively).DQB 1 *0303 was not associated with susceptibility to GD ( P=0.189,RR=0.64). There were no differences between male and female patients about HLA DQA 1 *0501,DQB 1 *0201 and DQB 1 *0303.Conclusion:HLA DQ is associated with GD in Chinese.Freqencies of HLA DQA 1 *0501 and DQB 1 *0201 decrease in Chinese patients with GD.
出处
《山东医科大学学报》
2001年第4期341-342,共2页
Acta Academiae Medicinae Shandong
