摘要
目的 探讨血管紧张素转化酶基因 (ACE)多态性与中国汉族老年人糖耐量低减 (IGT)及合并冠心病 (CAD)的关系。方法 使用多聚合酶链反应方法检测 79例糖耐量低减老年人和 49例糖耐量正常 (NGF)老年对照者的 ACE第 1 6内含子中长度为 2 87bp碱基片段的插入 /缺失(I/ D)情况。结果 IGT组 (n=79)和 NGT组 (n=40 )相比 ,D型等位基因和 DD基因型频率升高 (P<0 .0 5;P<0 .0 0 5) ;IGT合并冠心病组 (n=31 )和 IGT非冠心病组 (n=48)相比 ,DD基因型频率升高 (P<均 0 .0 0 5)。结论 ACE多态性和与老年人糖耐量低减冠心病相关 ,IGT和 DD基因型是老年冠心病的重要危险因子。
Objective To study the association between insertion/deletion(I/D) polymorphism of angiotensin converti ng enzyme (ACE) gene and impaired glucose tolerance(IGT) with coronary artery di sease (CAD).Methods The I/D of a 287 bp segmentum in intron 16 of ACE gene was detected by polymerase chain reaction in 79 senile IGT with CAD and 49 senile normal glucose tolerance (NGT) controls. Results D and DD genotype frequency was obviously higher in IGT group than in NGT group (P<0.05,P<0.005 respectively). The frequen cy of deletion allele was significantly higher in the IGT with CAD group than in IGT without CAD group (P<0.001).Conclusions The resu l ts demonstrate a close relationship between polymorphism of ACE gene and TGT wit h CAD and indicate both IGT and DD gene type are risk factors for CAD.
出处
《中国老年学杂志》
CAS
CSCD
北大核心
2001年第5期328-330,共3页
Chinese Journal of Gerontology
