摘要
目的 :探讨血清可溶性细胞间粘附分子 1 (s ICAM-1 )在新生儿败血症早期诊断中的价值。方法 :采用双抗体夹心酶联免疫吸附试验 ,观察 3组新生儿血清 s ICAM-1水平。脐血组 :34例正常新生儿脐血。对照组 :2 5例非感染性疾病新生儿。败血症组 :33例治疗前 (入院第 1 d)及有效治疗后 7～ 1 8d(出院当天 )的败血症新生儿。结果 :血清 s ICAM-1水平 3组间有显著差异 (P<0 .0 1 )。败血症组治疗前明显增高 ,治疗后略有下降 ,但治疗前后比较差异无意义 (P>0 .0 5 ) ;血培养阳性与阴性之间比较 ,不同程度败血症治疗前与治疗后比较 ,差异均无意义 (P均 >0 .0 5 )。结论 :血清s ICAM-1测定可作为新生儿败血症早期诊断指标 。
Objective: To investigate the clinical significance of serum soluble intercellular adhesion molecule l(sICAM 1) for early diagnosis of neonatal sepsis.Methods: The sandwich enzyme linked immunosorbent assay was used to measure sICAM 1 in 34 samples of normal neonatal cord blood (Group Ⅰ),25 normal newborns (GroupⅡ),33 cases of neonatal sepsis (8 with positive blood culture and 25 negative) before treatment and after recovery (Group Ⅲ).Results: There were significant difference in sICAM 1 levels amongⅠ,Ⅱ,Ⅲ group ( P <0.01). The sICAM 1 levels were higher in neonatal sepsis before treatment than those in normal newborn and persisted in high level in recovered patients. No difference was found between pre treatment and post treatment ( P >0.05),between patients with positive and negative blood culture,and between different intensity of sepsis ( P >0.05).Conclusion: sICAM 1 may be a specific early marker for neonatal sepsis,but it could not to evaluate the effect of treatment.
出处
《浙江大学学报（医学版）》
CAS
CSCD
2001年第3期119-121,共3页
Journal of Zhejiang University(Medical Sciences)
