摘要
利用分光光谱滴定法考察了钳形受体 1～ 4对氨基酸甲酯的识别性能 .结果表明 ,该类分子钳对D/L氨基酸甲酯具一定的对映选择性识别能力 .受体与底物间的大小 /形状匹配、几何互补性、微环境效应等对识别性能均有重要影响 .识别作用的主要推动力来自受体与底物之间的互补氢键、疏水区域的 van
The molecular recognition properties of four chiral molecular tweezers derived from deoxycholic acid for amino acid methyl esters have been investigated by UV Vis spectroscopic titration. The association constants ( K a) and Gibbs free energy changes (-Δ G 0) have been calculated. The results show that all the molecular tweezers 1~4 can form 1∶1 inclusion complexes with methyl esters of D/L phenylalanine and leucine. The recognition ability of these receptors comes mainly from hydrogen bonding and van der Waals interaction. The size/shape fitting and geometrical complement between receptor and substrate play an important role in the inclusion complexation of amino acid methyl esters with molecular tweezers 1~4.
出处
《应用化学》
CAS
CSCD
北大核心
2001年第8期614-617,共4页
Chinese Journal of Applied Chemistry
基金
国家自然科学基金资助项目 ( 2 0 0 72 0 2 6 )
关键词
手性识别
分子钳
脱氧胆酸
氨基酸酯
紫外光谱法
chiral recognition,molecular tweezer,deoxycholic acid,amino acid,UV spectroscopy
