摘要
目的 :探讨肝纤维化敏感可靠的血清学指标。方法 :用放射免疫法测定 113例慢性肝病患者血清Ⅲ型前胶原 (PCⅢ )、透明质酸 (HA)、层粘连蛋白 (LN)、IV型胶原 (IVC)并与其中 11例经肝组织活检后不同炎症分级和纤维化分期的患者进行对照观察 ,分析上述血清指标水平与肝组织分级和分期之间的关系。结果 :4项指标水平均与慢性肝炎发展的阶段一致 ,在慢性重度与肝硬化阶段水平最高。与肝组织炎症坏死及纤维化程度一致 ,相关系数结果显示 4项指标水平与纤维化的相关性高于炎症坏死相关性。结论 :4项指标检测可以反映肝纤维化程度 。
OBJECTIVE:To determine serum evidence of liver fibrosis. METHOD:Serum level of hyaluronic acid(HA),procollagen (PCⅢ),collagen Ⅳ(ⅣC)and LN were detected among 113 chronic liver disease patients.The results were compared with biopsy data of 11 examined liver disease patients.RESULTS:The serum level of above four substance was related to progress of chronic hepatitis and reached the highest level in severe hepatitis and cirosis.It was more corelated to fibrosis than to liver inflammatory necrosis.CONCLUSION:The serum level of PCⅢ,HA,LN and ⅣC can signal severity of liver fibrosis and provide evidence for treatment and evaluation of prognosis.
出处
《九江医学》
2001年第2期66-67,共2页
Jiujiang Medical Journal
