摘要
目的 探讨激素性股骨头坏死的发病机理。方法 2 2只雄性家兔随机分为两组 ,正常对照组 10只 ,模型组 12只 ,以肌注糖皮质激素诱导家兔股骨头坏死模型为对象 ,动态观察下丘脑 垂体 肾上腺皮质轴 (HPA)形态和功能变化 ,以及股骨头形态学变化。结果 激素性股骨头坏死模型其HPA轴从形态到功能出现抑制状态 ,表现为血浆皮质醇 (CORT)、促肾上腺皮质激素 (ACTH)降低 ,垂体、肾上腺明显萎缩 ,股骨头陷窝内骨细胞坏死。结论 HPA轴从形态到功能的全面抑制状态 。
Objective To investigate pathogenesis of steroidinducedavascularnecrosis of femoralhead (ANFH)Methods TheANFHmodelswereproducedin 2 2malerabbitsbyinjectingintramuscularlyglucocorti costeroidandtheanimalsweredividedintotwogroups:10rabbitsservedascontrolgroupand 12astheexperimental group .Themorphologicalandfunctionalchangeofhypothalamic pituitary adrenal(HPA)axisandthemorphologica changeoffemoralheadwereobservedintheexperiment.Results ThemorphologyandfunctionofHPAaxiswereob servedinexperimentalgroup ;thereweremarkeddecreaseofplasmacortisolandadrenocorticotropichormone,atrophy ofhypophysisandadrenal,osteocytenecrosisinfemoralheadlacuna .Theseweresignsofinhibitionofthefunctionof HPAaxis .Conclusion TheinhibitioneffectonthemorphologyandfunctionofHPAaxismaybeone of important pathogensis of steroid induced avascular necrosis of femoral head .
出处
《中国骨伤》
CAS
2001年第7期408-409,共2页
China Journal of Orthopaedics and Traumatology
关键词
股骨头坏死
糖皮质激素
病理学
Femur head necrosis Glucocorticoids Pathology
