摘要
目的 :探讨慢肾消对膜性肾炎治疗作用的机理。方法 :用阳离子化牛血清白蛋白 (C BSA)复制家兔膜性肾炎模型 ,分为慢肾消组、雷公藤组、模型组和正常组。每 2周检测 1次蛋白尿 ,实验结束时检测血浆白蛋白、总蛋白和胆固醇以及血栓素B2 (TxB2 )、6 酮 前列腺素 (6 keto PGF1a)。并进行光镜、电镜和免疫荧光的观察。结果 :慢肾消组和雷公藤组从第 4周开始 2 4h尿蛋白定量明显低于模型组 (P <0 0 1) ,而且血浆白蛋白、总蛋白以及胆固醇与模型组相比 ,均有明显改善 (P <0 0 5或P <0 0 1)。其中慢肾消提高血浆白蛋白、降低血浆胆固醇及TxB2 的作用明显优于雷公藤 (P <0 0 5) ,光镜、电镜和免疫荧光均发现两个用药组均较模型组病理损害减轻 ,尤以慢肾消组更为明显。结论 :慢肾消能减少尿蛋白 ,提高血浆总蛋白和白蛋白 ,降低血浆胆固醇 。
Objective:To explore the mechanism of the therapeutic effect of Manshenxiao on membranous nephritis. Methods:Forty male rabbits were made to membranous nephritis model by cation bovine serum albumin and divided into 4 groups, the groups A(treated by Manshenxiao),B(treated by multiglycosides tripterygil wilfordii),C(the control group)and D(the normal group). Twenty four hours'urinary protein content of the animals was examined every two weeks, and plasma albumin, total protein, cholesterin, thromboxanes B 2(TxB 2)and 6 keto PGF 1a were tested by the end of experiment. And light, electronic and immunofluorescent microscopy were adopted for observation. Results:The 24 hours' urinary protein content, plasma albumin, total protein and cholesterin were better than those in the control group significantly, P <0.01 or P <0.05. The group A was superior to group B in the function of promoting plasma albumin and lowering cholesterin and TxB 2, P <0.05. Light, electronic, and immunofluorescent microscopic examination all showed that the pathologic changes in the group A and B were lesser than that of the control group, and group A was the lest. Conclusion:Manshenxiao can reduce urinary protein content, elevate plasma albumin and total protein level, lower cholesterin level and remedy the pathologic changes of glomeruli.
出处
《中国中医基础医学杂志》
CAS
CSCD
2001年第7期36-38,共3页
JOURNAL OF BASIC CHINESE MEDICINE
基金
河北省教委资助课题!(NO 962 46)
