摘要
①目的 了解肺功能动态监测在咳嗽变异性哮喘疗效评价中的作用。②方法 对 42例咳嗽变异性哮喘病儿于发作期及缓解 0 .5 ,1.0年时进行常规肺功能及小气道功能检测。③结果 发作期肺功能各项指标明显异常 ,尤其是 5 0 %及 2 5 %肺活量时最大呼气流速与身高比 (V50 /Ht,V2 5/Ht)异常率达 92 .9% ,缓解 0 .5年时与发作期比较 ,其用力肺活量 (FVC)、第 1秒用力呼气容量 (FEV1.0 )、每分最大通气量 (MVV)、最大中段呼气流速 (MMF)、峰值呼气流速 (PEFR)有明显改善 (F =8.71～ 178.6 0 ,q=2 .83～ 9.37,P <0 .0 5 ,0 .0 1) ,但小气道功能损害仍明显 ,V50 /Ht,V2 5/Ht基本正常者仅 6例 (14.3% )。而缓解 1.0年时肺功能各项指标与 0 .5年对比又有明显改善 (q =2 .93～17.19,P <0 .0 5 ,0 .0 1)。小气道功能基本正常率达 73 .81% .④结论 咳嗽变异性哮喘经长期而系统的治疗后肺功能可以得到改善 。
Objective\ To probe the role of dynamic monitoring for pulmonary function in long term treatment of cough variant asthma. \ Methods\ We measured pulmonary and little airways function of 42 children with cough variant asthma treated in acute stage and in 0.5,1.0 year after remission. \ Results\ All parameters of pulmonary function in acute stage were obviously abnormal. After 6 months of remission , the pulmonary function was improved ( F=8.71-178.60,q=2.83-9.37, P <0.05, 0.01 ); but the damage of little airways function was still obvious in most of them, only 6 children were normal (14.3%); after 1 year of remission , all parameters of pulmonary function were much better than those in six months( q= 2.93-17.19, P < 0.05 ,0.01); the little airways function of 31 children was normal (73.81%).\ Conclusion\ This study demonstrates that little airways function of children with cough variant asthma can be improved by long term systemic treatment and dynamic monitor of pulmonary function is an effective way to evaluate the clinical efficacy.
出处
《齐鲁医学杂志》
2001年第3期182-183,共2页
Medical Journal of Qilu
