摘要
耐药性的出现极大限制了氨基糖苷类药物的应用 ,随着分子生物学技术的发展 ,对这类药物耐药机理的研究也一直在深入之中。耐药性的出现主要是由于药物累积的减少 。
The emergence of resistance strains has limit ed the application of aminoglycosides greatlyAnd the development of molecular biology techniques enables us to study mechanisms of resistance conveniently and deeplyThe main mechanism s are (1)decreased accumulation of drugs (2)inactivation by aminoglycoside-modi fying enzymes (3)alteration of the ribosomal binding sites
出处
《药物生物技术》
CAS
CSCD
2001年第3期174-177,共4页
Pharmaceutical Biotechnology
