摘要
目的 探讨药物对高原人体运动前后血液流变学的影响。方法 对进驻海拔 410 0m高原 2 0天的 40名健康青年随机分为红景天组、乙酰唑胺组、西氏胶囊组和对照组 ,每组 10人 ,在安静时、服药前、后及踏阶运动后分别检测红细胞压积 (HCT)、血液粘度 (ηb)、血浆粘度 (ηp)、还原粘度 (ηr)、红细胞刚性指数 (IR)、红细胞变形系数(TK)、红细胞聚集系数 (VAI)及血栓形成系数 (TFL)。结果 服药前运动后较运动前四组各指标均降低 (P <0 .0 5～0 .0 1) ;服药后对照组和乙酰唑胺组均降低 ,红景天组 ηb、ηp、ηr、IR、TK、VAI均降低 ,西氏胶囊组 ηb、ηp、ηr、IR、TK、VAI、TFL均降低 (P <0 .0 5～ 0 .0 1)。服药后较服药前对照组各指标均无统计学意义 (P >0 .0 5 ) ;运动前服药后较服药前三组药物 ηb、ηp、IR、TK、VAI、TFL均降低 ,运动后 ηb、ηp 降低显著 (P <0 .0 5～ 0 .0 1)。结论 几种药物均只有改善组织微循环及血液流变性的作用。
Objective:To study the effects of drugs on hemorrheology before and afetr exercise at high altitude.Methods:The 40 healthy youth were randomly divided into 4 groups (Rholida,Acetazolamide,Xi′s capsule and Control group),who have stayed high altitude (4100m) for 20 days to determine their HCT,η b,η p,η r,IR,TK,VAI and TFL at rest state,before and after taking drugs,and after stair-exercise.Result:All those indexes decrease of after stair-exercise (P<0.05 or 0.01).After taking drugs for 6 days,the Rholida group′s η b,η p,η r,IR,TK and VAI decreased,the Xi′s capsule group′s indexes except HCT decreased,and all those indexes of Actazolamide group decreased (P<0.05 or 0.01),but there is no statistics meaning in Control group(P>0.05).Before stair-exercise,the η b,η p,IR,TK,VAI and TFL decreased afetr taking drugs,but after stair-exercise,the η b,η p decreased notably in three drug groups (P<0.05 or 0.01).Conclusion:Rholida,Acetazolamide and Xi′s capsule could improve the tissne microcircultion and hemorrheology at altitude.
出处
《中国血液流变学杂志》
CAS
2001年第2期121-124,共4页
Chinese Journal of Hemorheology
