摘要
目的 观察鼻咽癌患者放疗前后血中超氧化物歧化酶 (SOD)水平变化。方法 鼻咽癌患者 46例 ,正常对照组 32例 ,检测其血液中放疗前后SOD含量改变。结果 放疗前鼻咽癌患者SOD水平 (76 .2 1NU/ml±2 8.2 8NU/ml)明显低于对照组 (10 1.0 3NU/ml± 37.39NU/ml) ,放疗后有明显提高 (10 1.86NU/ml± 31.5 0NU/ml)。放疗前鼻咽癌Ⅱ期SOD水平 (88.5NU/ml± 32 .36NU/ml)高于Ⅲ期 (70 .34NU/ml± 2 9.73NU/ml)及Ⅳ期(75 .9NU/ml± 2 0 .98NU/ml)。放疗后SOD水平CR(肿瘤完全缓解 )组 (10 3.2 1NU/ml± 30 .85NU/ml)稍高于PR(肿瘤部分缓解 )组 (97.2 3NU/ml± 2 9.89NU/ml)。
Objective To observe the content changes of superoxide dismutase (SOD) in nasopharyngeal carcinoma (NPC) patients before and after radiotherapy. Methods SOD content of the blood was examined in 46 NPC patients before and after radiotherapy and in 32 normal controls. Results SOD content in NPC patients ( 76.21 NU/ml± 28.28 NU/ml) before radiotherapy was significantly lower than that of the controls ( 101.03 NU/ml± 37.39 NU/ml), but increased significantly after radiotherapy ( 101.86 NU/ml± 31.50 NU/ml). SOD content in Stage Ⅱ NPC ( 88.5 NU/ml± 32.36 NU/ml) was higher than that in Stage Ⅲ ( 70.34 NU/ml± 29.73 NU/ml) and Stage Ⅳ ( 75.9 NU/ml± 20.98 NU/ml). SOD content of the CR(complete relief) group ( 103.21 NU/ml± 30.85 NU/ml) was a little higher than that of the PR(partial relief) group ( 97.23 NU/ml± 29.89 NU/ml) after radiotherapy. Conclusion A negative correlation was found between SOD content and the tumor size and NPC clinical stage.
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
2001年第2期89-90,共2页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
关键词
鼻咽肿瘤
鳞状细胞癌
超氧化物歧化酶
放射治疗
Nasopharyngeal neoplasms/enzymol
Carcinoma, Squamous cell/enzymol
Superoxide dismutase/metab
